What is Symblepharon?

A symblepharon is a fibrous tract that connects bulbar conjunctiva toconjunctiva on the eyelid.

Symblepharon, Normal Fornix

Cosmetic & Reconstructive Facial Eyelid & Orbital surgery @ Eye Plastics.


Symblepharon, Upper Fornix

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When do symblepharon occur?

  • Cicatricial pemphigoid; auto-immune disease which affects mucus membranes such as the mouth and oral pharynx, conjunctiva, nares and genitalia
  • Atopic keratoconjunctivitis: This is a hypersensitivity to environmental allergies including asthma, rhinitis, dermatitis and eczema.
  • Trichiasis: A lid abnormality in which eyelashes are misdirected towards the eyeball. These misdirected lashes may possibly often be the result of scarring.
  • Toxic epidermal necrosis (TEN): A potentially life-threatening disorder which is commonly drug-induced.
  • Stevens Johnson Syndrome
    • Characteristics:
      • Equal age and sex distribution
      • disease associated with a 5-15% mortality rate
      • Ocular involvement in 50%
      • Associated with various infections and medications most notably sulfa
      Ocular involvement in 50%
    • Pathogenesis:
      • Angiitis-->Erythematous lesion-->Bullae-->Rupture-->Scar
    • Prodrome:
      • Fever, chills, and headache
      • 7 days later bullous mucosal lesions develop
    • Sequelae:
      • Problems are related to the destruction of Goblet cells and a lack of conjunctival mucus which leads to keratinization and scarring.
      • Lid scarring with symblepharon
      • Corneal scarring
      • Keratitis sicc
  • Burns
  • Erythema multiforme: This is an acute multi-cutaneous hypersensitivity reaction

What are the treatment options?

  • Why use Amniotic membrane? Because it:
    • facilitates epithelialization
    • maintains normal epithelial phenotype (with goblet cells when performed on conjunctiva ),
    • reduce inflammation, vascularization and scarring.

The use of {human} amniotic membrane for the surgical treatment of an ocular surface disorder was initially reported by de Rotth 16 in 1940. During the 1990s, the role of amniotic membrane transplantation in treating a variety of ocular surface defects and abnormalities has been revived.


Chemical Burns

Image of an eye condition called Symblepharon, showing the adhesion between the eyelid and the eyeball


A medical image showing symblepharon. Width: 229 pixels, Height: 158 pixels

Corneal/Sclera Ulceration & 


Image showing amniocentesis procedure


Image of symblepharon medical condition

 Stevens-Johnson's Syndrome

A medical image showing symblepharon, a condition where the conjunctiva of the eye becomes adhered to the cornea. Width: 228px, Height: 159px.